Viola, Alessia;
Monteleone, Alessandra;
Napoli, Enrico;
Burriesci, Gaetano;
(2023)
Modelling of thrombus formation using smoothed particle hydrodynamics method.
PLoS One
, 18
(2)
, Article e0281424. 10.1371/journal.pone.0281424.
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Abstract
In this paper a novel model, based on the smoothed particle hydrodynamics (SPH) method, is proposed to simulate thrombus formation. This describes the main phases of the coagulative cascade through the balance of four biochemical species and three type of platelets. SPH particles can switch from fluid to solid phase when specific biochemical and physical conditions are satisfied. The interaction between blood and the forming blood clot is easily handled by an innovative monolithic FSI approach. Fluid-solid coupling is modelled by introducing elastic binds between solid particles, without requiring detention and management of the interface between the two media. The proposed model is able to realistically reproduce the thromboembolic process, as confirmed by the comparison of numerical results with experimental data available in the literature.
| Type: | Article |
|---|---|
| Title: | Modelling of thrombus formation using smoothed particle hydrodynamics method |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0281424 |
| Publisher version: | https://doi.org/10.1371/journal.pone.0281424 |
| Language: | English |
| Additional information: | Copyright: © 2023 Monteleone et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10163799 |
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