Jehl, Markus;
Mikhaylova, Ekaterina;
Treyer, Valerie;
Hofbauer, Marlena;
Hüllner, Martin;
Kaufmann, Philipp A;
Buck, Alfred;
... Fischer, Jannis; + view all
(2022)
Attenuation Correction Using Template PET Registration for Brain PET: A Proof-of-Concept Study.
Journal of Imaging
, 9
(1)
, Article 2. 10.3390/jimaging9010002.
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Abstract
NeuroLF is a dedicated brain PET system with an octagonal prism shape housed in a scanner head that can be positioned around a patient’s head. Because it does not have MR or CT capabilities, attenuation correction based on an estimation of the attenuation map is a crucial feature. In this article, we demonstrate this method on [18F]FDG PET brain scans performed with a low-resolution proof of concept prototype of NeuroLF called BPET. We perform an affine registration of a template PET scan to the uncorrected emission image, and then apply the resulting transform to the corresponding template attenuation map. Using a whole-body PET/CT system as reference, we quantitively show that this method yields comparable image quality (0.893 average correlation to reference scan) to using the reference µ-map as obtained from the CT scan of the imaged patient (0.908 average correlation). We conclude from this initial study that attenuation correction using template registration instead of a patient CT delivers similar results and is an option for patients undergoing brain PET.
| Type: | Article |
|---|---|
| Title: | Attenuation Correction Using Template PET Registration for Brain PET: A Proof-of-Concept Study |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/jimaging9010002 |
| Publisher version: | https://doi.org/10.3390/jimaging9010002 |
| Language: | English |
| Additional information: | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | tomography; attenuation correction; image reconstruction; brain; PET; STIR; Nifty-Reg; registration |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10162993 |
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