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Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion

Chaguza, Chrispin; Jamrozy, Dorota; Bijlsma, Merijn W; Kuijpers, Taco W; van de Beek, Diederik; van der Ende, Arie; Bentley, Stephen D; (2022) Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion. Nature Communications , 13 , Article 4215. 10.1038/s41467-022-31858-4. Green open access

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Abstract

Group B Streptococcus (GBS), or Streptococcus agalactiae, is a pathogen that causes preterm births, stillbirths, and acute invasive neonatal disease burden and mortality. Here, we investigate bacterial genetic signatures associated with disease onset time and meningeal tissue infection in acute invasive neonatal GBS disease. We carry out a genome-wide association study (GWAS) of 1,338 GBS isolates from newborns with acute invasive disease; the isolates had been collected annually, for 30 years, through a national bacterial surveillance program in the Netherlands. After controlling for the population structure, we identify genetic variation within noncoding and coding regions, particularly the capsule biosynthesis locus, statistically associated with neonatal GBS disease onset time and meningeal invasion. Our findings highlight the impact of integrating microbial population genomics and clinical pathogen surveillance, and demonstrate the effect of GBS genetics on disease pathogenesis in neonates and infants.

Type: Article
Title: Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41467-022-31858-4
Publisher version: https://doi.org/10.1038/s41467-022-31858-4
Language: English
Additional information: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Keywords: Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, EPIDEMIOLOGY, MENINGITIS, CAPSULE, PROTEIN, POLYSACCHARIDE, NETHERLANDS, FIBRINOGEN, NEWBORNS, INFANT
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/10160971
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