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Feasibility of Image Reconstruction from Triple Modality Data of Yttrium-90

Deidda, D; Denis-Bacelar, A; Fenwick, A; Ferreira, K; Heetun, W; Hutton, BF; Scuffham, J; ... Thielemans, K; + view all (2022) Feasibility of Image Reconstruction from Triple Modality Data of Yttrium-90. In: 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2021 and 28th International Symposium on Room-Temperature Semiconductor Detectors, RTSD 2022. IEEE: Piscataway, NJ, USA. Green open access

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Abstract

The recent implementation of the first clinical triple modality scanner in STIR enables investigation of the possibility of triple modality image reconstruction. Such a tool represents an important step toward the improvement of dosimetry for theranostics, where the exploitation of multi-modality imaging can have an impact on treatment planning and follow-up. To give a demonstration of triple modality image reconstruction we used data from a NEMA phantom that was filled with Yttrium-90 (90Y), which emits Bremsstrahlung photons detectable with SPECT as well as gamma rays that can go through pair production, therefore creating positrons that make PET acquisition possible. The data were acquired with the Mediso AnyScan SPECT/PET/CT. Different ways of including multiple side information using the kernelised expectation maximisation (KEM) and the Hybrid KEM (HKEM) were used and investigated in terms of ROI activity and noise suppression. This work presents an example of application with 90Y but it can be extended to any other radionuclide combination used in Theranostic applications.

Type: Proceedings paper
Title: Feasibility of Image Reconstruction from Triple Modality Data of Yttrium-90
Event: 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)
Dates: 16 Oct 2021 - 23 Oct 2021
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/NSS/MIC44867.2021.9875695
Publisher version: https://doi.org/10.1109/NSS/MIC44867.2021.9875695
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Production, Positrons, Imaging phantoms, Dosimetry, Planning, Single photon emission computed tomography, Positron emission tomography
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging
URI: https://discovery.ucl.ac.uk/id/eprint/10160470
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