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The importance of ancestry to understanding tumor mutation burden in cancer

Snyder, Alexandra; McGranahan, Nicholas; (2022) The importance of ancestry to understanding tumor mutation burden in cancer. Cancer Cell , 40 (10) pp. 1076-1078. 10.1016/j.ccell.2022.09.004. Green open access

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Abstract

In the current issue of Cancer Cell, Nassar and colleagues find that in solid tumors, tumor-only sequencing leads to an overestimate of the biomarker tumor mutation burden (TMB), particularly in patients of African or Asian ancestry. Correction of the TMB estimate improves the correlation between TMB and response to immunotherapy.

Type: Article
Title: The importance of ancestry to understanding tumor mutation burden in cancer
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ccell.2022.09.004
Publisher version: https://doi.org/10.1016/j.ccell.2022.09.004
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Oncology, Cell Biology
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10160446
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