Yang, Jangmi;
Kim, Hae-Young;
Park, Seup;
Sentissi, Ilham;
Green, Nathan;
Oh, Byung Kwon;
Kim, Yujin;
... Lee, Seung Heon; + view all
(2022)
Cost-effectiveness of a medication event monitoring system for tuberculosis management in Morocco.
PLOS ONE
, 17
(4)
, Article e0267292. 10.1371/journal.pone.0267292.
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Abstract
BACKGROUND: Digital health technologies have been used to enhance adherence to TB medication, but the cost-effectiveness remains unclear. METHODS: We used the real data from the study conducted from April 2014 to December 2020 in Morocco using a smart pillbox with a web-based medication monitoring system, called Medication Event Monitoring Systems (MEMS). Cost-effectiveness was evaluated using a decision analysis model including Markov model for Multi-drug resistant (MDR) TB from the health system perspective. The primary outcome was the incremental cost-effectiveness ratio (ICER) per disability adjusted life-year (DALY) averted. Two-way sensitive analysis was done for the treatment success rate between MEMS and standard of care. RESULTS: The average total per-patient health system costs for treating a new TB patient under MEMS versus standard of care were $398.70 and $155.70, respectively. The MEMS strategy would reduce the number of drug-susceptible TB cases by 0.17 and MDR-TB cases by 0.01 per patient over five years. The ICER of MEMS was $434/DALY averted relative to standard of care, and was most susceptible to the TB treatment success rate of both strategies followed by the managing cost of MEMS. CONCLUSION: MEMS is considered cost-effective for managing infectious active TB in Morocco.
| Type: | Article |
|---|---|
| Title: | Cost-effectiveness of a medication event monitoring system for tuberculosis management in Morocco |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0267292 |
| Publisher version: | https://doi.org/10.1371/journal.pone.0267292 |
| Language: | English |
| Additional information: | Copyright © 2022 Yang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Keywords: | Tuberculosis, Multi-drug-resistant tuberculosis, Drug therapy, Treatment guidelines, Cost-effectiveness analysis, Morocco, Death rates, Tuberculosis diagnosis and management |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Statistical Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10160160 |
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