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Evaluating Lipid-Lowering Drug Targets for Parkinson's Disease Prevention with Mendelian Randomization

Williams, Dylan; Bandres-Ciga, Sara; Heilbron, Karl; Hinds, David; Noyce, Alastair; The 23andMe Research Team; The International Parkinson's Disease Genomics Consortium; (2020) Evaluating Lipid-Lowering Drug Targets for Parkinson's Disease Prevention with Mendelian Randomization. Annals of Neurology , 88 (5) pp. 1043-1047. 10.1002/ana.25880. Green open access

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Abstract

Long-term exposure to lipid-lowering drugs might affect Parkinson's disease (PD) risk. We conducted Mendelian randomization analyses where genetic variants indexed expected effects of modulating lipid-lowering drug targets on PD. Statin exposure was not predicted to increase PD risk, although results were not precise enough to support benefits for prevention clearly (odds ratio [OR] = 0.83; 95% confidence interval [CI] = 0.65, 1.07). Other target results were null, except for variants indicating Apolipoprotein-A5 or Apolipoprotein-C3 inhibition might confer protection. These findings suggest peripheral lipid variation may not have a prominent role in PD etiology, but some related drug targets could influence PD via alternate pathways. ANN NEUROL 2020;88:1043–1047

Type: Article
Title: Evaluating Lipid-Lowering Drug Targets for Parkinson's Disease Prevention with Mendelian Randomization
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/ana.25880
Publisher version: https://doi.org/10.1002/ana.25880
Language: English
Additional information: © 2020 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine > MRC Unit for Lifelong Hlth and Ageing
URI: https://discovery.ucl.ac.uk/id/eprint/10159694
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