Navaratnam, Annalan MD;
Shrotri, Madhumita;
Nguyen, Vincent;
Braithwaite, Isobel;
Beale, Sarah;
Byrne, Thomas E;
Fong, Wing Lam Erica;
... Virus Watch Collaborative; + view all
(2022)
Nucleocapsid and spike antibody responses post virologically confirmed SARS-CoV-2 infection: An observational analysis in the Virus Watch community cohort.
International Journal of Infectious Diseases
10.1016/j.ijid.2022.07.053.
(In press).
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Abstract
Objectives: Seroprevalence studies can provide a measure of SARS-CoV-2 cumulative incidence, but a better understanding of spike (anti-S) and nucleocapsid (anti-N) antibody dynamics following infection is needed to assess longevity of detectability. / Methods: Adults aged ≥18 years old, from households enrolled in the Virus Watch prospective community cohort study in England and Wales, provided monthly capillary-blood samples which were tested for anti-S and anti-N. Participants self-reported vaccination dates and past medical history. Prior polymerase chain reaction (PCR) swabs were obtained through Second Generation Surveillance System (SGSS) linkage data. Primary outcome variables were seropositivity and total anti-N and anti-S levels after PCR confirmed infection. / Results: A total of 13,802 eligible individuals provided 58,770 capillary blood samples. 537 of these had a prior positive PCR confirmed SARS-CoV-2 infection within 0-269 days of antibody sample date, with 432 (80.45%) having a positive anti-N result. Median anti-N levels peaked between days 90 and 119 post PCR results and then began to decline. There is evidence of anti-N waning from 120 days onwards, with earlier waning for females and younger age categories. / Conclusion: Our findings suggests that anti-N have around 80% sensitivity for identifying previous COVID-19 infection and duration of detectability is affected by sex and age.
| Type: | Article |
|---|---|
| Title: | Nucleocapsid and spike antibody responses post virologically confirmed SARS-CoV-2 infection: An observational analysis in the Virus Watch community cohort |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ijid.2022.07.053 |
| Publisher version: | https://doi.org/10.1016/j.ijid.2022.07.053 |
| Language: | English |
| Additional information: | Copyright © 2022 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Anti-N, anti-S, serosurveillance, COVID-19, corona virus |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics > Infectious Disease Informatics UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10154174 |
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