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The Role of Hsp90 in Retinal Proteostasis and Disease

Ziaka, Kalliopi; van der Spuy, Jacqueline; (2022) The Role of Hsp90 in Retinal Proteostasis and Disease. Biomolecules , 12 (7) , Article 978. 10.3390/biom12070978. Green open access

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Abstract

Photoreceptors are sensitive neuronal cells with great metabolic demands, as they are responsible for carrying out visual phototransduction, a complex and multistep process that requires the exquisite coordination of a large number of signalling protein components. Therefore, the viability of photoreceptors relies on mechanisms that ensure a well-balanced and functional proteome that maintains the protein homeostasis, or proteostasis, of the cell. This review explores how the different isoforms of Hsp90, including the cytosolic Hsp90α/β, the mitochondrial TRAP1, and the ER-specific GRP94, are involved in the different proteostatic mechanisms of photoreceptors, and elaborates on Hsp90 function when retinal homeostasis is disturbed. In addition, several studies have shown that chemical manipulation of Hsp90 has significant consequences, both in healthy and degenerating retinae, and this can be partially attributed to the fact that Hsp90 interacts with important photoreceptor-associated client proteins. Here, the interaction of Hsp90 with the retina-specific client proteins PDE6 and GRK1 will be further discussed, providing additional insights for the role of Hsp90 in retinal disease.

Type: Article
Title: The Role of Hsp90 in Retinal Proteostasis and Disease
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/biom12070978
Publisher version: https://doi.org/10.3390/biom12070978
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Hsp90, chaperone, co-chaperone, heat shock protein, inherited retinal disease, photoreceptor, phototransduction, proteostasis, HSP90 Heat-Shock Proteins, Humans, Photoreceptor Cells, Proteostasis, Retina
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10153614
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