Roccarina, D;
Iogna Prat, L;
Pallini, G;
Guerrero Misas, M;
Buzzetti, E;
Saffioti, F;
Aricò, FM;
... Tsochatzis, EA; + view all
(2022)
Comparison of point-shear wave elastography (ElastPQ) and transient elastography (FibroScan) for liver fibrosis staging in patients with non-alcoholic fatty liver disease.
Liver International
10.1111/liv.15297.
(In press).
![[thumbnail of Tsochatzis_Manuscript revised without editing marks.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/text.png) |
Text
Tsochatzis_Manuscript revised without editing marks.pdf Access restricted to UCL open access staff until 16 June 2023. Download (417kB) |
Abstract
Background and Aims: ElastPQ is a point shear wave elastography technique used to non-invasively assess liver fibrosis. We compared liver stiffness measurements (LSM) by ElastPQ and fibroscan transient elastography (F-TE) in a cohort of patients with non-alcoholic fatty liver disease (NAFLD). We further evaluated the performance of ElastPQ in a subgroup of patients with available liver histology. Materials and Methods: We included patients with NAFLD who presented in a dedicated multidisciplinary clinic. Anthropometric parameters, blood tests and elastography measurements were obtained using F-TE and ElastPQ as part of routine clinical care. Results: We enrolled 671 patients with NAFLD, mean age 55.8 ± 13 years, body mass index (BMI) 31.5 ± 5.7 kg/m2, 56.6% males, 41% diabetes, 53.7% hypertension, 68% dyslipidaemia. ElastPQ showed an excellent correlation with F-TE (Spearman's r = 0.80, p <.001), which was better for mild/moderate stages of fibrosis. Independent predictors of a >2 kPa discrepancy between the two techniques were a larger waist circumference and F-TE ≥10 kPa. In the subgroup of 159 patients with available histology, ElastPQ showed similar diagnostic accuracy with F-TE in staging liver fibrosis (ElastPQ area under the curves 0.84, 0.83, 0.86 and 0.95, for F ≥ 1, F ≥ 2, F ≥ 3 and F = 4 respectively). Optimal cut-off values of ElastPQ for individual fibrosis stages were lower than those of F-TE. Conclusions: ElastPQ shows an excellent correlation with F-TE in patients with NAFLD, which was better for lower LSM. The optimal cut-off values of ElastPQ are lower than those of F-TE for individual stages of fibrosis. ElastPQ has similar diagnostic accuracy to F-TE for all stages of fibrosis.
| Type: | Article |
|---|---|
| Title: | Comparison of point-shear wave elastography (ElastPQ) and transient elastography (FibroScan) for liver fibrosis staging in patients with non-alcoholic fatty liver disease |
| Location: | United States |
| DOI: | 10.1111/liv.15297 |
| Publisher version: | https://doi.org/10.1111/liv.15297 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Gastroenterology & Hepatology, acoustic radiation force impulse, Elast-PQ point-shear wave elastography, liver elastography, liver fibrosis, non-alcoholic fatty liver disease, transient elastography, RADIATION FORCE IMPULSE, CHRONIC HEPATITIS-C, NONINVASIVE ASSESSMENT, ARFI ELASTOGRAPHY, DIAGNOSIS, REPRODUCIBILITY, QUANTIFICATION, PERFORMANCE, TECHNOLOGY, GUIDELINES |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10152857 |
Archive Staff Only
 |
View Item |
