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Circulating microRNAs and Clinicopathological Findings of Papillary Thyroid Cancer: A Systematic Review

Geropoulos, Georgios; PSARRAS, KYRIAKOS; PAPAIOANNOU, MARIA; GIANNIS, DIMITRIOS; MEITANIDOU, MARIA; KAPRINIOTIS, KONSTANTINOS; SYMEONIDIS, NIKOLAOS; ... EDDAMA, MOHAMMADMR; + view all (2022) Circulating microRNAs and Clinicopathological Findings of Papillary Thyroid Cancer: A Systematic Review. In Vivo , 36 (4) pp. 1551-1569. 10.21873/invivo.12866. Green open access

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Abstract

BACKGROUND/AIM: Papillary thyroid cancer (PTC) is the most common endocrine malignancy with a rising incidence. There is a need for a non-invasive preoperative test to enable better patient counselling. The aim of this systematic review was to investigate the potential role of circulating microRNAs (miRNAs) in the diagnosis and prognosis of PTC. MATERIALS AND METHODS: A systematic literature search was performed using MEDLINE, Cochrane, and Scopus databases (last search date was December 1, 2021). Studies investigating the expression of miRNAs in the serum or plasma of patients with PTC were deemed eligible for inclusion. RESULTS: Among the 1,533 screened studies, 39 studies met the inclusion criteria. In total, 108 miRNAs candidates were identified in the serum, plasma, or exosomes of patients suffering from PTC. Furthermore, association of circulating miRNAs with thyroid cancer-specific clinicopathological features, such as tumor size (13 miRNAs), location (3 miRNAs), extrathyroidal extension (9 miRNAs), pre- vs. postoperative period (31 miRNAs), lymph node metastasis (17 miRNAs), TNM stage (9 miRNAs), BRAF V600E mutation (6 miRNAs), serum thyroglobulin levels (2 miRNAs), 131I avid metastases (13 miRNAs), and tumor recurrence (2 miRNAs) was also depicted in this study. CONCLUSION: MiRNAs provide a potentially promising role in the diagnosis and prognosis of PTC. There is a correlation between miRNA expression profiles and specific clinicopathological features of PTC. However, to enable their use in clinical practice, further clinical studies are required to validate the predictive value and utility of miRNAs as biomarkers.

Type: Article
Title: Circulating microRNAs and Clinicopathological Findings of Papillary Thyroid Cancer: A Systematic Review
Location: Greece
Open access status: An open access version is available from UCL Discovery
DOI: 10.21873/invivo.12866
Publisher version: https://doi.org/10.21873/invivo.12866
Language: English
Additional information: Copyright © 2022, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license (https://creativecommons.org/licenses/by-nc-nd/4.0).
Keywords: Science & Technology, Life Sciences & Biomedicine, Medicine, Research & Experimental, Research & Experimental Medicine, miRNA, microRNA, clinicopathological features, papillary thyroid cancer, thyroid neoplasms, review, LYMPH-NODE METASTASIS, CLINICAL CHARACTERISTICS, BRAF(V600E) MUTATION, POTENTIAL BIOMARKERS, EXPRESSION PROFILES, DICER1 MUTATIONS, DOWN-REGULATION, CARCINOMA, DIAGNOSIS, NODULES
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
URI: https://discovery.ucl.ac.uk/id/eprint/10152369
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