Ganguli, Sushila;
(2022)
The Effects of Oncogenic Ras on Epithelial Cell Division.
Doctoral thesis (Ph.D), UCL (University College London).
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Abstract
The devastating diagnosis of cancer arises in part from the deregulation of cell division. However, it is not known how these cells divide across the range of environments encountered during cancer progression. In this thesis, I investigate the effects of oncogenic Ras on the biology of epithelial cell division. Through this work I find that Ras-ERK signalling not only increases mitotic rounding but also alters the dynamics and division axis of cells as they divide and respread. This reduces the ability of nascent daughters to assume the mother cell footprint and appears to result from effects on cell adhesion that normally provide a memory of cell shape. Significantly, these effects occur within five hours of oncogene expression and are rapidly inhibited by Ras-ERK inhibitors. Together, these findings show how activation of a single oncogene can directly change the fundamental act of cell division as a relatively early event in oncogenesis.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | The Effects of Oncogenic Ras on Epithelial Cell Division |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2022. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10152200 |
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