UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Materials and extracellular matrix rigidity highlighted in tissue damages and diseases: Implication for biomaterials design and therapeutic targets

Park, Jae Hee; Jo, Seung Bin; Lee, Jung-Hwan; Lee, Hae-Hyoung; Knowles, Jonathan C; Kim, Hae-Won; (2023) Materials and extracellular matrix rigidity highlighted in tissue damages and diseases: Implication for biomaterials design and therapeutic targets. Bioactive Materials , 20 pp. 381-403. 10.1016/j.bioactmat.2022.06.003. Green open access

[thumbnail of Knowles_Materials and extracellular matrix rigidity highlighted in tissue damages and diseases_VoR.pdf]
Preview
Text
Knowles_Materials and extracellular matrix rigidity highlighted in tissue damages and diseases_VoR.pdf - Published Version

Download (15MB) | Preview

Abstract

Rigidity (or stiffness) of materials and extracellular matrix has proven to be one of the most significant extracellular physicochemical cues that can control diverse cell behaviors, such as contractility, motility, and spreading, and the resultant pathophysiological phenomena. Many 2D materials engineered with tunable rigidity have enabled researchers to elucidate the roles of matrix biophysical cues in diverse cellular events, including migration, lineage specification, and mechanical memory. Moreover, the recent findings accumulated under 3D environments with viscoelastic and remodeling properties pointed to the importance of dynamically changing rigidity in cell fate control, tissue repair, and disease progression. Thus, here we aim to highlight the works related with material/matrix-rigidity-mediated cell and tissue behaviors, with a brief outlook into the studies on the effects of material/matrix rigidity on cell behaviors in 2D systems, further discussion of the events and considerations in tissue-mimicking 3D conditions, and then examination of the in vivo findings that concern material/matrix rigidity. The current discussion will help understand the material/matrix-rigidity-mediated biological phenomena and further leverage the concepts to find therapeutic targets and to design implantable materials for the treatment of damaged and diseased tissues.

Type: Article
Title: Materials and extracellular matrix rigidity highlighted in tissue damages and diseases: Implication for biomaterials design and therapeutic targets
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bioactmat.2022.06.003
Publisher version: https://doi.org/10.1016/j.bioactmat.2022.06.003
Language: English
Additional information: © 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. under a Creative Commons license (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Matrix rigidity, Biophysical cue, Cell and tissue engineering, 3D biomaterials conditions, Therapeutic targets
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10150887
Downloads since deposit
151Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item