Majd, Hamta;
Harker, Anthony;
Edirisinghe, Mohan;
Parhizkar, Maryam;
(2022)
Optimised release of tetracycline hydrochloride from core-sheath fibres produced by pressurised gyration.
Journal of Drug Delivery Science and Technology
, 72
, Article 103359. 10.1016/j.jddst.2022.103359.
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Abstract
In recent years, there has been a surge of interest in the design, processing, and use of core-sheath fibres, especially in the production of wound healing bandages and drug delivery. In this research, a novel core-sheath pressurised gyration technique was utilised to create antibacterial fibre patches (tetracycline hydrochloride, TEHCL) using polyvinyl pyrrolidone (PVP) and polycaprolactone (PCL). Antibiotic patches showed uniform fibres with a porous surface giving rise to a biphasic delivery system, which provided an initial burst of 30–48% drug release in the first 24 h followed by a constant rate of release throughout the course of 168 h, suitable for wound-dressings application. The effect of operating parameters on fibre morphology, the influence of the coresheath structure and drug loading as well as a mathematical modelling was investigated and analysed. Fouriertransform infrared spectroscopy, and differential scanning calorimetry results demonstrated successful TEHCL encapsulation as well as the presence of both polymers in the core-sheath fibres. The surface morphology of the fibres was studied using scanning electron microscopy and the core-sheath structure was verified using confocal scanning microscopy. Therefore, the core-sheath pressurised gyration method offers an exciting chance to customise fibre patches in a hybrid polymeric system. These advancements are crucial in the world of healthcare to meet demands where antibacterial dressings cannot be produced rapidly or when a personalised approach is necessary.
| Type: | Article |
|---|---|
| Title: | Optimised release of tetracycline hydrochloride from core-sheath fibres produced by pressurised gyration |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jddst.2022.103359 |
| Publisher version: | https://doi.org/10.1016/j.jddst.2022.103359 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Pharmacology & Pharmacy, Core-sheath, Polymer, Pressurised gyration, Fibre, Drug delivery, Wound healing, DRUG-RELEASE, ELECTROSPUN NANOFIBERS, POLYMER NANOFIBERS, WOUND CARE, TRANSITION, SCAFFOLDS, MECHANISM, DRESSINGS, POROSITY, HOLLOW |
| UCL classification: | UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering UCL > Provost and Vice Provost Offices > UCL BEAMS UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10150648 |
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