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Methyltransferases: Functions and Applications

Abdelraheem, Eman; Thair, Benjamin; Varela, Romina Fernández; Jockmann, Emely; Popadić, Désirée; Hailes, Helen C; Ward, John M; ... Hanefeld, Ulf; + view all (2022) Methyltransferases: Functions and Applications. ChemBioChem , 23 (18) , Article e202200212. 10.1002/cbic.202200212. Green open access

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Abstract

In this review the current state of the art of S-adenosylmethionine (SAM)-dependent methyltransferases and SAM are evaluated. Their structural classification and diversity is introduced and key mechanistic aspects presented which are then detailed further. Then, catalytic SAM as a target for drugs and approaches to utilise SAM as a cofactor in synthesis is introduced with different recycling approaches evaluated. The use of SAM analogues are also described. Finally O-, N-, C- and S-MTs, their synthetic applications and potential for compound diversification is given.

Type: Article
Title: Methyltransferases: Functions and Applications
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/cbic.202200212
Publisher version: https://doi.org/10.1002/cbic.202200212
Language: English
Additional information: © 2022 The Authors. ChemBioChem published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
Keywords: Methyltransferase, S-adenosyl-L-methionine, Enzyme, biocatalysis
UCL classification: UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10150643
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