Abdelraheem, Eman;
Thair, Benjamin;
Varela, Romina Fernández;
Jockmann, Emely;
Popadić, Désirée;
Hailes, Helen C;
Ward, John M;
... Hanefeld, Ulf; + view all
(2022)
Methyltransferases: Functions and Applications.
ChemBioChem
, 23
(18)
, Article e202200212. 10.1002/cbic.202200212.
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Abstract
In this review the current state of the art of S-adenosylmethionine (SAM)-dependent methyltransferases and SAM are evaluated. Their structural classification and diversity is introduced and key mechanistic aspects presented which are then detailed further. Then, catalytic SAM as a target for drugs and approaches to utilise SAM as a cofactor in synthesis is introduced with different recycling approaches evaluated. The use of SAM analogues are also described. Finally O-, N-, C- and S-MTs, their synthetic applications and potential for compound diversification is given.
| Type: | Article |
|---|---|
| Title: | Methyltransferases: Functions and Applications |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/cbic.202200212 |
| Publisher version: | https://doi.org/10.1002/cbic.202200212 |
| Language: | English |
| Additional information: | © 2022 The Authors. ChemBioChem published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Methyltransferase, S-adenosyl-L-methionine, Enzyme, biocatalysis |
| UCL classification: | UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering UCL > Provost and Vice Provost Offices > UCL BEAMS UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10150643 |
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