Sharif-Askari, Fatemeh Saheb;
Sharif-Askari, Narjes Saheb;
Goel, Swati;
Mahboub, Bassam;
Ansari, Abdul Wahid;
Temsah, Mohamad-Hani;
Zakri, Adel M;
... Halwani, Rabih; + view all
(2021)
Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity.
ERJ Open Research
, 7
(3)
, Article 00984-2020. 10.1183/23120541.00984-2020.
Preview |
Text
Upregulation of interleukin-19 in severe asthma a potential saliva biomarker for asthma severity. .pdf - Published Version Download (751kB) | Preview |
Abstract
Interleukin (IL)-19, a designated IL-20 subfamily cytokine, has been implicated in inflammatory disorders including rheumatoid arthritis, psoriasis and, lately, asthma. Here, through the analysis of transcriptomic datasets of lung tissue of large asthma cohorts, we report that IL-19 expression is upregulated in asthma and correlates with disease severity. The gene expression of IL-19 was significantly higher in lung tissue from patients with severe and mild/moderate asthma compared to healthy controls. IL-19 protein level, however, was significantly higher in the blood and saliva of patients with severe asthma compared to mild/ moderate subgroups as measured by ELISA assay. IL-19 protein level was not affected by corticosteroid treatment in plasma. Our data provide insights into the potential use of IL-19 as a saliva marker for asthma severity and a potential therapeutic target.
| Type: | Article |
|---|---|
| Title: | Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1183/23120541.00984-2020 |
| Publisher version: | https://doi.org/10.1183/23120541.00984-2020 |
| Language: | English |
| Additional information: | This version is distributed under the terms of the Creative Commons Attribution NonCommercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org This article has supplementary material available from openres.ersjournals.com. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Respiratory System, BRONCHIAL EPITHELIAL-CELLS, IL-19, EXPRESSION, CYTOKINES, IL-20, INFLAMMATION, ACTIVATION, GENES, TH2 |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10148937 |
Archive Staff Only
 |
View Item |
