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Lateral gain is impaired in macular degeneration and can be targeted to restore vision in mice

Rizzi, M; Powell, K; Robinson, MR; Matsuki, T; Hoke, J; Maswood, RN; Georgiadis, A; ... Ali, RR; + view all (2022) Lateral gain is impaired in macular degeneration and can be targeted to restore vision in mice. Nature Communications , 13 , Article 2159. 10.1038/s41467-022-29666-x. Green open access

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Abstract

Macular degeneration is a leading cause of blindness. Treatments to rescue vision are currently limited. Here, we study how loss of central vision affects lateral feedback to spared areas of the human retina. We identify a cone-driven gain control mechanism that reduces visual function beyond the atrophic area in macular degeneration. This finding provides an insight into the negative effects of geographic atrophy on vision. Therefore, we develop a strategy to restore this feedback mechanism, through activation of laterally projecting cells. This results in improved vision in Cnga3−/− mice, which lack cone function, as well as a mouse model of geographic atrophy. Our work shows that a loss of lateral gain control contributes to the vision deficit in macular degeneration. Furthermore, in mouse models we show that lateral feedback can be harnessed to improve vision following retinal degeneration.

Type: Article
Title: Lateral gain is impaired in macular degeneration and can be targeted to restore vision in mice
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41467-022-29666-x
Publisher version: https://doi.org/10.1038/s41467-022-29666-x
Language: English
Additional information: © 2022 Springer Nature Limited. This article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/).
Keywords: Animals, Geographic Atrophy, Macular Degeneration, Mice, Retinal Cone Photoreceptor Cells, Retinal Degeneration, Vision, Ocular
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: https://discovery.ucl.ac.uk/id/eprint/10147945
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