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Measuring Inflammation in the Vitreous and Retina: A Narrative Review

Kale, Aditya U; Serrano, Alba; Liu, Xiaoxuan; Balasubramaniam, Balini; Keane, Pearse A; Moore, David J; Llorenc, Victor; (2022) Measuring Inflammation in the Vitreous and Retina: A Narrative Review. Ocular Immunology and Inflammation 10.1080/09273948.2022.2049316. (In press).

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Abstract

Uveitis consists of a group of syndromes characterised by intraocular inflammation, accounting for up to 15% of visual loss in the western world and 10% worldwide. Assessment of intraocular inflammation has been limited to clinician-dependent, subjective grading. Developments in imaging technology, such as optical coherence tomography (OCT), have enabled the development of objective, quantitative measures of inflammatory activity. Important quantitative metrics including central macular thickness and vitreous signal intensity allow longitudinal monitoring of disease activity and can be used in conjunction with other imaging modalities enabling holistic assessment of ocular inflammation. Ongoing work into the validation of instrument-based measures alongside development of core outcome sets is crucial for standardisation of clinical trial endpoints and developing guidance for quantitative multi-modal imaging approaches. This review outlines methods of grading inflammation in the vitreous and retina, with a focus on the use of OCT as an objective measure of disease activity.

Type: Article
Title: Measuring Inflammation in the Vitreous and Retina: A Narrative Review
Location: England
DOI: 10.1080/09273948.2022.2049316
Publisher version: https://doi.org/10.1080/09273948.2022.2049316
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Imaging, inflammation, ocular, ophthalmology, optical coherence tomography, uveitis
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10147743
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