Jiang, Yunsong;
Torun, Tugce;
Maffioletti, Sara M;
Serio, Andrea;
Tedesco, Francesco Saverio;
(2022)
Bioengineering human skeletal muscle models: Recent advances, current challenges and future perspectives.
Experimental Cell Research
, 416
(2)
, Article 113133. 10.1016/j.yexcr.2022.113133.
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Abstract
Engineering models of human skeletal muscle tissue provides unique translational opportunities to investigate and develop therapeutic strategies for acute muscle injuries, and to establish personalised and precision medicine platforms for in vitro studies of severe neuromuscular and musculoskeletal disorders. Several myogenic and non-myogenic cell types can be isolated, generated, amplified and combined with scaffolds and biomaterials to achieve this aim. Novel bio-fabrication strategies, which include exogenous stimuli to enhance tissue maturation, promise to achieve an ever-increasing degree of tissue functionalisation both in vivo and in vitro. Here we review recent advances, current challenges and future perspectives to build human skeletal muscle tissue "in a dish", focusing on the cellular constituents and on applications for in vitro disease modelling. We also briefly discuss the impact that emerging technologies such as 3D bioprinting, organ-on-chip and organoids might have to circumvent current technical hurdles in future studies.
| Type: | Article |
|---|---|
| Title: | Bioengineering human skeletal muscle models: Recent advances, current challenges and future perspectives |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.yexcr.2022.113133 |
| Publisher version: | https://doi.org/10.1016/j.yexcr.2022.113133 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | 3D scaffolds, Biomaterials, Human skeletal muscle, Myogenic cells, Tissue engineering |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10147102 |
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