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Characterisation of ethnic differences in DNA methylation between UK resident South Asians and Europeans

Elliott, Hannah R; Burrows, Kimberley; Min, Josine L; Tillin, Therese; Mason, Dan; Wright, John; Santorelli, Gillian; ... Relton, Caroline L; + view all (2022) Characterisation of ethnic differences in DNA methylation between UK resident South Asians and Europeans. Cold Spring Harbor Laboratory: Cold Spring Harbor (NY), USA. Green open access

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Abstract

Ethnic differences in non-communicable disease risk have been described between individuals of South Asian and European ethnicity that are only partially explained by genetics and other known risk factors. DNA methylation is one underexplored mechanism that may explain differences in disease risk. Currently there is little knowledge of how DNA methylation varies between South Asian and European ethnicities. This study characterised differences in blood DNA methylation between individuals of self-reported European and South Asian ethnicity from two UK-based cohorts; Southall and Brent Revisited (SABRE) and Born in Bradford (BiB). DNA methylation differences between ethnicities were widespread throughout the genome (n=16,433 CpG sites, 3.4% sites tested). Specifically, 76% of associations were attributable to ethnic differences in cell composition with fewer effects attributable to smoking and genetic variation. Ethnicity associated CpG sites were enriched for EWAS Catalog phenotypes including metabolites. This work highlights the need to consider ethnic diversity in epigenetic research.

Type: Working / discussion paper
Title: Characterisation of ethnic differences in DNA methylation between UK resident South Asians and Europeans
Open access status: An open access version is available from UCL Discovery
DOI: 10.1101/2022.04.06.22273496
Publisher version: https://doi.org/10.1101/2022.04.06.22273496
Language: English
Additional information: © The Authors 2022. The copyright holder for this preprint is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine > MRC Unit for Lifelong Hlth and Ageing
URI: https://discovery.ucl.ac.uk/id/eprint/10146896
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