Kuusisto, Sanna;
Karjalainen, Minna K;
Tillin, Therese;
Kangas, Antti J;
Holmes, Michael V;
Kähönen, Mika;
Lehtimäki, Terho;
... Ala-Korpela, Mika; + view all
(2022)
Genetic and observational evidence: No independent role for cholesterol efflux over static HDL concentration measures in CHD risk assessment.
Journal of Internal Medicine
, 292
(1)
pp. 146-153.
10.1111/joim.13479.
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Abstract
BACKGROUND: Observational findings for HDL-mediated cholesterol efflux capacity (HDL-CEC) and coronary heart disease (CHD) appear inconsistent, and knowledge of the genetic architecture of HDL-CEC is limited. OBJECTIVES: A large-scale observational study of the associations of HDL-CEC and other HDL-related measures with CHD and the largest genome-wide association study (GWAS) of HDL-CEC. PARTICIPANTS/METHODS: Six independent cohorts were included with follow-up data for 14,438 participants to investigate the associations of HDL-related measures with incident CHD (1,570 events). The GWAS of HDL-CEC was carried out in 20,372 participants. RESULTS: HDL-CEC did not associate with CHD when adjusted for traditional risk factors and HDL-C. In contradiction, almost all HDL-related concentration measures associated consistently with CHD after corresponding adjustments. There were no genetic loci associated with HDL-CEC independent of HDL-C and triglycerides. CONCLUSION: HDL-CEC is not unequivocally associated with CHD in contrast to HDL cholesterol, apolipoprotein A-I and most of the HDL subclass particle concentrations. This article is protected by copyright. All rights reserved.
| Type: | Article |
|---|---|
| Title: | Genetic and observational evidence: No independent role for cholesterol efflux over static HDL concentration measures in CHD risk assessment |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/joim.13479 |
| Publisher version: | https://doi.org/10.1111/joim.13479 |
| Language: | English |
| Additional information: | Copyright © 2022 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | HDL, cholesterol efflux, coronary heart disease, genome-wide association study, observational cohort study, triglycerides |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine > MRC Unit for Lifelong Hlth and Ageing UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10145682 |
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