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Patient-Specific Modelling and Parameter Optimisation to Simulate Dilated Cardiomyopathy in Children

Bozkurt, Selim; Paracha, Waleed; Bakaya, Kaushiki; Schievano, Silvia; (2022) Patient-Specific Modelling and Parameter Optimisation to Simulate Dilated Cardiomyopathy in Children. Cardiovascular Engineering and Technology 10.1007/s13239-022-00611-9. (In press). Green open access

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Abstract

PURPOSE: Lumped parameter modelling has been widely used to simulate cardiac function and physiological scenarios in cardiovascular research. Whereas several patient-specific lumped parameter models have been reported for adults, there is a limited number of studies aiming to simulate cardiac function in children. The aim of this study is to simulate patient-specific cardiovascular dynamics in children diagnosed with dilated cardiomyopathy, using a lumped parameter model. METHODS: Patient data including age, gender, heart rate, left and right ventricular end-systolic and end-diastolic volumes, cardiac output, systolic and diastolic aortic pressures were collected from 3 patients at Great Ormond Street Hospital for Children, London, UK. Ventricular geometrical data were additionally retrieved from cardiovascular magnetic resonance images. 23 parameters in the lumped parameter model were optimised to simulate systolic and diastolic pressures, end-systolic and end-diastolic volumes, cardiac output and left and right ventricular diameters in the patients using a direct search optimisation method. RESULTS: Difference between the haemodynamic parameters in the optimised cardiovascular system models and clinical data was less than 10%. CONCLUSION: The simulation results show the potential of patient-specific lumped parameter modelling to simulate clinical cases. Modelling patient specific cardiac function and blood flow in the paediatric patients would allow us to evaluate a variety of physiological scenarios and treatment options.

Type: Article
Title: Patient-Specific Modelling and Parameter Optimisation to Simulate Dilated Cardiomyopathy in Children
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s13239-022-00611-9
Publisher version: https://doi.org/10.1007/s13239-022-00611-9
Language: English
Additional information: Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Keywords: Lumped parameter model, Patient-specific cardiac function, Dilated cardiomyopathy, Paediatrics, DYNAMICS, SYSTEM, VOLUME
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Childrens Cardiovascular Disease
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10144860
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