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Examining the relationship between altered brain functional connectome and disinhibition across 33 impulsive and compulsive behaviours

Chye, Y; Suo, C; Romero-Garcia, R; Bethlehem, RAI; Hook, R; Tiego, J; Goodyer, I; ... Chamberlain, SR; + view all (2021) Examining the relationship between altered brain functional connectome and disinhibition across 33 impulsive and compulsive behaviours. The British Journal of Psychiatry , 220 (2) pp. 76-78. 10.1192/bjp.2021.49. Green open access

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Abstract

Impulsive and compulsive problem behaviours are associated with a variety of mental disorders. Latent phenotyping indicates the expression of impulsive and compulsive problem behaviours is predominantly governed by a transdiagnostic 'disinhibition' phenotype. In a cohort of 117 individuals, recruited as part of the Neuroscience in Psychiatry Network (NSPN), we examined how brain functional connectome and network properties relate to disinhibition. Reduced functional connectivity within a subnetwork of frontal (especially right inferior frontal gyrus), occipital and parietal regions was linked to disinhibition. Findings provide insights into neurobiological pathways underlying the emergence of impulsive and compulsive disorders.

Type: Article
Title: Examining the relationship between altered brain functional connectome and disinhibition across 33 impulsive and compulsive behaviours
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1192/bjp.2021.49
Publisher version: https://doi.org/10.1192/bjp.2021.49
Language: English
Additional information: This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists
Keywords: Impulsivity, brain network, compulsivity, connectome, transdiagnostic
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10142536
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