Chye, Y;
Suo, C;
Romero-Garcia, R;
Bethlehem, RAI;
Hook, R;
Tiego, J;
Goodyer, I;
... Chamberlain, SR; + view all
(2021)
Examining the relationship between altered brain functional connectome and disinhibition across 33 impulsive and compulsive behaviours.
The British Journal of Psychiatry
, 220
(2)
pp. 76-78.
10.1192/bjp.2021.49.
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Abstract
Impulsive and compulsive problem behaviours are associated with a variety of mental disorders. Latent phenotyping indicates the expression of impulsive and compulsive problem behaviours is predominantly governed by a transdiagnostic 'disinhibition' phenotype. In a cohort of 117 individuals, recruited as part of the Neuroscience in Psychiatry Network (NSPN), we examined how brain functional connectome and network properties relate to disinhibition. Reduced functional connectivity within a subnetwork of frontal (especially right inferior frontal gyrus), occipital and parietal regions was linked to disinhibition. Findings provide insights into neurobiological pathways underlying the emergence of impulsive and compulsive disorders.
| Type: | Article |
|---|---|
| Title: | Examining the relationship between altered brain functional connectome and disinhibition across 33 impulsive and compulsive behaviours |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1192/bjp.2021.49 |
| Publisher version: | https://doi.org/10.1192/bjp.2021.49 |
| Language: | English |
| Additional information: | This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists |
| Keywords: | Impulsivity, brain network, compulsivity, connectome, transdiagnostic |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10142536 |
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