Ingley, KM; Maleddu, A; Le Grange, F; Gerrand, C; Bleyer, A; Yasmin, E; Whelan, J; Ingley, KM; Maleddu, A; Le Grange, F; Gerrand, C; Bleyer, A; Yasmin, E; Whelan, J; Strauss, SJ; - view fewer (2022) Current approaches to management of bone sarcoma in adolescent and young adult patients. Pediatric Blood & Cancer , 69 (2) , Article e29442. 10.1002/pbc.29442.

Text Strauss_Ingley_et al -AYA bone sarcomas.pdf - Accepted Version Access restricted to UCL open access staff until 13 November 2022. Download (917kB)

Abstract

Bone tumors are a group of histologically diverse diseases that occur across all ages. Two of the commonest, osteosarcoma (OS) and Ewing sarcoma (ES), are regarded as characteristic adolescent and young adult (AYA) cancers with an incidence peak in AYAs. They are curable for some but associated with unacceptably high rates of treatment failure and morbidity. The introduction of effective new therapeutics for bone sarcomas is slow, and to date, complex biology has been insufficiently characterized to allow more rapid therapeutic exploitation. This review focuses on current standards of care, recent advances that have or may soon change that standard of care and challenges to the expert clinical research community that we suggest must be met.

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