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Current approaches to management of bone sarcoma in adolescent and young adult patients

Ingley, KM; Maleddu, A; Le Grange, F; Gerrand, C; Bleyer, A; Yasmin, E; Whelan, J; (2022) Current approaches to management of bone sarcoma in adolescent and young adult patients. Pediatric Blood & Cancer , 69 (2) , Article e29442. 10.1002/pbc.29442.

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Abstract

Bone tumors are a group of histologically diverse diseases that occur across all ages. Two of the commonest, osteosarcoma (OS) and Ewing sarcoma (ES), are regarded as characteristic adolescent and young adult (AYA) cancers with an incidence peak in AYAs. They are curable for some but associated with unacceptably high rates of treatment failure and morbidity. The introduction of effective new therapeutics for bone sarcomas is slow, and to date, complex biology has been insufficiently characterized to allow more rapid therapeutic exploitation. This review focuses on current standards of care, recent advances that have or may soon change that standard of care and challenges to the expert clinical research community that we suggest must be met.

Type: Article
Title: Current approaches to management of bone sarcoma in adolescent and young adult patients
DOI: 10.1002/pbc.29442
Publisher version: https://doi.org/10.1002/pbc.29442
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: adolescent and young adult (AYA); bone sarcoma; clinical trials; Ewing sarcoma; local control; osteosarcoma; radiation; surgery
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10142360
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