Pokharkar, V;
Sajith, M;
Vallet, T;
Akshantal, S;
Shah, R;
Ruiz, F;
Salunke, S;
(2021)
Acceptability of different oral dosage forms in paediatric patients in hospital setting.
Archives of Disease in Childhood
10.1136/archdischild-2021-322604.
(In press).
Preview |
Text
Salunke_Acceptability paper ADC_manuscript _final1.pdf - Accepted Version Download (194kB) | Preview |
Abstract
Objective The understanding of acceptability of existing dosage forms is limited in most of the world and hinders the development of acceptable, age‐appropriate medicines. The attributes of paediatric medicine acceptability may differ from country to country based on culture, healthcare infrastructure and health policies. This study was designed to map the acceptability of oral medicines in paediatric patients treated in hospital in India. Methods An observational, cross-sectional study was conducted in patients aged below 18 years and taking any form of oral medication. Acceptability scores were obtained using CAST–ClinSearch Acceptability Score Test tool. Findings 490 patients were recruited and 193 evaluations of different pharmaceutical products available in 20 dosage forms and 7 routes of administration were studied. Oral liquids (50%) and tablets (35%) were the most commonly prescribed and administered forms. Regardless of the therapeutic class and age, the oral liquids were ‘positively accepted’ in infants and toddlers. Acceptability of tablets improved with age and appeared to be generally good from the age of 6. Conclusion This study indicates the limited progress towards adoption of age-appropriate dosage forms in India and thus impact on the acceptability of existing oral dosage forms. The key challenges posed by the adoption of age-appropriate formulations in India are (1) awareness of importance of appropriate administration and acceptability of medicines to children in India, (2) availability of age-appropriate dosage forms and (3) lack of child-appropriate medicine policies.
| Type: | Article |
|---|---|
| Title: | Acceptability of different oral dosage forms in paediatric patients in hospital setting |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1136/archdischild-2021-322604 |
| Publisher version: | http://dx.doi.org/10.1136/archdischild-2021-322604 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Pediatrics, dosage form, pharmaceutical preparations, age appropriate, child, medicines, administration and dosage, DENTAL-CARIES, RISK-FACTORS, MEDICINES, CHILDREN, FORMULATION, INFANTS, ACCEPTANCE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10141594 |
Archive Staff Only
 |
View Item |
