Chan, EWW; Leung, MTY; Lau, LKW; Leung, J; Lum, D; Wong, RS-M; Li, X; ... Lai, FTT; + view all Chan, EWW; Leung, MTY; Lau, LKW; Leung, J; Lum, D; Wong, RS-M; Li, X; Chui, CSL; Wan, EYF; Wong, CKH; Chan, EWY; Ip, P; Wong, ICK; Lai, FTT; - view fewer (2022) Comparing self-reported reactogenicity between adolescents and adults following the use of BNT162b2 (Pfizer-BioNTech) messenger RNA Covid-19 vaccine: a prospective cohort study. International Journal of Infectious Diseases 10.1016/j.ijid.2021.12.354. (In press).

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Abstract

Objectives: Although clinical data have shown that the BNT162b2 vaccine, which is widely used in many countries, is safe and effective as a protection against the Covid-19 infection, extant research in adverse reactions using real-world data of various socio-demographic characteristics is scant. Methods: We conducted a prospective cohort study to compare age differences in self-reported reactogenicity of BNT162b2 in Hong Kong. A total of 1,516 participants were intensively followed up for two weeks following both doses of BNT162b2 vaccination, during which their basic demographic, health conditions, and medication information were collected. Results: Results from generalized mixed model showed that compared with adults aged 18 – 59, older adults aged 60 or above had a lower risk of adverse reactions, and adolescents aged 12 – 17 had a moderately higher risk. Conclusions: Results of this study should be informative to parents considering BNT162b2 vaccination for their children in that moderately increased reactogenicity compared with adults is anticipated.

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