UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Regional cerebral and splanchnic tissue oxygen saturation in preterm infants – longitudinal normative measurements

Howarth, C; Leung, T; Banerjee, J; Eaton, S; Morris, J; Aladangady, N; (2022) Regional cerebral and splanchnic tissue oxygen saturation in preterm infants – longitudinal normative measurements. Early Human Development , 165 , Article 105540. 10.1016/j.earlhumdev.2022.105540. Green open access

[thumbnail of NIRS normal distribution article_EHD_accepted.pdf]
Preview
Text
NIRS normal distribution article_EHD_accepted.pdf - Accepted Version

Download (398kB) | Preview

Abstract

BACKGROUND: To investigate regional splanchnic and cerebral tissue oxygen saturation in preterm infants <30 weeks gestation. METHODS: Cerebral (cTOI) and splanchnic (sTOI) Tissue Oxygenation Index were measured weekly in 5 min epochs for a total period of 60 min using NIRS (NIRO-300) for the first 8 weeks of life, in 48 appropriately grown preterm infants born at <30 weeks gestation. Infants who developed HPI and/or NEC (n = 12) and those that died (n = 1) were excluded from our main outcome measure of regional gut and cerebral tissue oxygenation in healthy preterm infants <30 weeks gestation. RESULTS: Median birthweight 789 g (460–1486), gestational age 25+6 weeks (23+0–29+1) and 51.4% female. 217 NIRS measurements were completed across the first 8 weeks of life. Mean weekly cTOI ranged from 56.8–65.4% and sTOI ranged from 36.7–46.0%. Mean cTOI was significantly higher than mean sTOI (p < 0.001) throughout the first 8 weeks of life. Mean cTOI decreased significantly with increasing postnatal age [−0.59% each week (−1.26% to −0.07%) p = 0.04]. None of the examined confounding factors had a significant effect. CONCLUSIONS: This is the first report of regional cerebral and splanchnic tissue oxygen saturation ranges during the first 8 weeks of life for preterm infants born at <30 weeks gestation.

Type: Article
Title: Regional cerebral and splanchnic tissue oxygen saturation in preterm infants – longitudinal normative measurements
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.earlhumdev.2022.105540
Publisher version: https://doi.org/10.1016/j.earlhumdev.2022.105540
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10141334
Downloads since deposit
23Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item