Shakouri, Taleen Sally;
(2021)
Synthesis, Characterisation and 3D Printing of a Light-Curable Degradable Polymer for Craniofacial Bone Regeneration.
Doctoral thesis (Ph.D), UCL (University College London).
Preview |
Text
FINAL THESIS - Taleen Shakouri.pdf - Accepted Version Download (6MB) | Preview |
Abstract
A surgeon’s options for correcting congenital deformities, removing oral tumours and reconstructing the head and neck region are typically restricted by the equipment available to restore bone function and appearance for the patient. New production techniques and implants with improved osseointegration performance are urgently needed to meet the growing demand for effective implants at a reasonable price. Non-degradable materials are used widely for bone repair; however, they will stay in the body indefinitely until removed surgically. Metals, such as titanium, can be used for three-dimensional (3D) printing of scaffolds. 3D printing has the potential to enhance the creation of anatomically fitting patient-specific devices with highly effective delivery in a cost-effective manner. However, metal implants have the disadvantage that they can release traces of material over time and induce immunological responses. Non-degradable polymers, such as poly (methyl methacrylate), have the disadvantages that they undergo highly exothermic polymerisation, are prone to infection and lack osseointegration. Ceramics, such as calcium phosphates, have also been studied for use in craniofacial bone regeneration, however, they have poor fracture toughness, brittleness and excessive stiffness. In view of the disadvantages associated with several of the known 3D printable materials, this thesis takes you through the development of an improved material that addresses some of the disadvantages discussed above. In this study, the synthesis of the new material referred to as “CSMA-2” is investigated along with its mechanical properties and the effects of the addition of different ratios of calcium phosphate fillers to the isosorbide-based, light-curable, degradable polymer. A comparison between two different photoinitiator systems is carried out throughout this study to ultimately find the most suited formulation for the 3D printing of the resin. Mechanical tests showed the modulus values to be between 1.7-3 kN/mm2 in CSMA-2 and its composites dependant on the photoinitiator system used. In vitro cell culture studies, using human bone osteosarcoma cells and human adipose-derived stem cells confirmed cytocompatibility of the material. Finally, Digital Light Processing 3D printing, allowed a direct photo-polymerisation of the resin to form bone- like scaffolds ready to be implanted in vivo.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | Synthesis, Characterisation and 3D Printing of a Light-Curable Degradable Polymer for Craniofacial Bone Regeneration |
| Event: | UCL |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2021. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10140715 |
Archive Staff Only
 |
View Item |
