Cardenal-Muñoz, E;
Auvin, S;
Villanueva, V;
Cross, JH;
Zuberi, SM;
Lagae, L;
Aibar, JÁ;
(2021)
Guidance on Dravet Syndrome from Infant to Adult Care: Road Map for Treatment Planning in Europe.
Epilepsia Open
10.1002/epi4.12569.
(In press).
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Epilepsia Open - 2021 - Cardenal‐Mu oz - Guidance on Dravet Syndrome from Infant to Adult Care Road Map for Treatment.pdf - Accepted Version Download (55MB) | Preview |
Abstract
Dravet syndrome (DS) is a severe, rare and complex developmental and epileptic encephalopathy affecting 1 in 16'000 live births and characterized by a drug resistant epilepsy, cognitive, psychomotor and language impairment, as well as behavioral disorders. Evidence suggests that optimal treatment of seizures in DS may improve outcomes, even though neurodevelopmental impairments are the likely result of both the underlying genetic variant and the epilepsy. We present an updated guideline for DS diagnosis and treatment, taking into consideration care of the adult patient and non-pharmaceutical therapeutic options for this disease. This up-to-date guideline, which is based on an extensive review of the literature and culminates with a new treatment algorithm for DS, is a European consensus developed through a survey involving 29 European clinical experts in DS. Theis guideline will serve professionals in their clinical practice and, as a consequence, will benefit DS patients and their families.
| Type: | Article |
|---|---|
| Title: | Guidance on Dravet Syndrome from Infant to Adult Care: Road Map for Treatment Planning in Europe |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/epi4.12569 |
| Publisher version: | https://doi.org/10.1002/epi4.12569 |
| Language: | English |
| Additional information: | This article is protected by copyright. All rights reserved. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| Keywords: | Antiseizure medication, comorbidities, epilepsy, genetic diagnosis, treatment algorithm |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10140493 |
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