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Control of parallel hippocampal output pathways by amygdalar long-range inhibition

Alsubaie, R; Wee, RWS; Ritoux, A; Mishchanchuk, K; Passlack, J; Regester, D; Macaskill, AF; (2021) Control of parallel hippocampal output pathways by amygdalar long-range inhibition. eLife , 10 , Article e74758. 10.7554/eLife.74758. (In press). Green open access

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Abstract

Projections from the basal amygdala (BA) to the ventral hippocampus (vH) are proposed to provide information about the rewarding or threatening nature of learned associations to support appropriate goal-directed and anxiety-like behaviour. Such behaviour occurs via the differential activity of multiple, parallel populations of pyramidal neurons in vH that project to distinct downstream targets, but the nature of BA input and how it connects with these populations is unclear. Using channelrhodopsin-2-assisted circuit mapping in mice, we show that BA input to vH consists of both excitatory and inhibitory projections. Excitatory input specifically targets BA- and nucleus accumbens-projecting vH neurons and avoids prefrontal cortex-projecting vH neurons, while inhibitory input preferentially targets BA-projecting neurons. Through this specific connectivity, BA inhibitory projections gate place-value associations by controlling the activity of nucleus accumbens-projecting vH neurons. Our results define a parallel excitatory and inhibitory projection from BA to vH that can support goal-directed behaviour.

Type: Article
Title: Control of parallel hippocampal output pathways by amygdalar long-range inhibition
Open access status: An open access version is available from UCL Discovery
DOI: 10.7554/eLife.74758
Publisher version: https://doi.org/10.7554/eLife.74758
Language: English
Additional information: © 2021, AlSubaie et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/10139948
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