UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation

Lau, C; Yánez, DC; Papaioannou, E; Ross, S; Crompton, T; (2021) Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation. The FEBS Journal 10.1111/febs.16222. (In press). Green open access

[thumbnail of Crompton_The FEBS Journal - 2021 - Lau - Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation.pdf]
Preview
Text
Crompton_The FEBS Journal - 2021 - Lau - Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation.pdf

Download (1MB) | Preview

Abstract

Epithelial barrier tissues such as the skin and airway form an essential interface between the mammalian host and its external environment. These physical barriers are crucial to prevent damage and disease from environmental insults and allergens. Failure to maintain barrier function against such risks can lead to severe inflammatory disorders, including atopic dermatitis and asthma. Here, we discuss the role of the morphogen Sonic Hedgehog in postnatal skin and lung and the impact of Shh signalling on repair, inflammation and atopic disease in these tissues.

Type: Article
Title: Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/febs.16222
Publisher version: https://doi.org/10.1111/febs.16222
Language: English
Additional information: © 2021 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: inflammation, lung, skin, sonic hedgehog, T-cell
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10136406
Downloads since deposit
52Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item