Lau, C;
Yánez, DC;
Papaioannou, E;
Ross, S;
Crompton, T;
(2021)
Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation.
The FEBS Journal
10.1111/febs.16222.
(In press).
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Abstract
Epithelial barrier tissues such as the skin and airway form an essential interface between the mammalian host and its external environment. These physical barriers are crucial to prevent damage and disease from environmental insults and allergens. Failure to maintain barrier function against such risks can lead to severe inflammatory disorders, including atopic dermatitis and asthma. Here, we discuss the role of the morphogen Sonic Hedgehog in postnatal skin and lung and the impact of Shh signalling on repair, inflammation and atopic disease in these tissues.
| Type: | Article |
|---|---|
| Title: | Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/febs.16222 |
| Publisher version: | https://doi.org/10.1111/febs.16222 |
| Language: | English |
| Additional information: | © 2021 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | inflammation, lung, skin, sonic hedgehog, T-cell |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10136406 |
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