Vrenken, H;
Jenkinson, M;
Pham, D;
Guttmann, CRG;
Pareto, D;
Paardekooper, M;
de Sitter, A;
... MAGNIMS Study Group; + view all
(2021)
Opportunities for Understanding MS Mechanisms and Progression With MRI Using Large-Scale Data Sharing and Artificial Intelligence.
Neurology
10.1212/WNL.0000000000012884.
(In press).
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Abstract
Multiple sclerosis (MS) patients have heterogeneous clinical presentations, symptoms and progression over time, making MS difficult to assess and comprehend in vivo. The combination of large-scale data-sharing and artificial intelligence creates new opportunities for monitoring and understanding MS using magnetic resonance imaging (MRI).First, development of validated MS-specific image analysis methods can be boosted by verified reference, test and benchmark imaging data. Using detailed expert annotations, artificial intelligence algorithms can be trained on such MS-specific data. Second, understanding disease processes could be greatly advanced through shared data of large MS cohorts with clinical, demographic and treatment information. Relevant patterns in such data that may be imperceptible to a human observer could be detected through artificial intelligence techniques. This applies from image analysis (lesions, atrophy or functional network changes) to large multi-domain datasets (imaging, cognition, clinical disability, genetics, etc.).After reviewing data-sharing and artificial intelligence, this paper highlights three areas that offer strong opportunities for making advances in the next few years: crowdsourcing, personal data protection, and organized analysis challenges. Difficulties as well as specific recommendations to overcome them are discussed, in order to best leverage data sharing and artificial intelligence to improve image analysis, imaging and the understanding of MS.
| Type: | Article |
|---|---|
| Title: | Opportunities for Understanding MS Mechanisms and Progression With MRI Using Large-Scale Data Sharing and Artificial Intelligence |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1212/WNL.0000000000012884 |
| Publisher version: | https://doi.org/10.1212/WNL.0000000000012884 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10136320 |
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