UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Single-Nucleotide Polymorphisms within the cps Loci: Another Potential Source of Clinically Important Genetic Variation for Streptococcus pneumoniae?

Brown, JS; (2021) Single-Nucleotide Polymorphisms within the cps Loci: Another Potential Source of Clinically Important Genetic Variation for Streptococcus pneumoniae? Infection and Immunity , 89 (11) , Article e00374-21. 10.1128/IAI.00374-21. Green open access

[thumbnail of IAI.00374-21.pdf]
Preview
Text
IAI.00374-21.pdf - Accepted Version

Download (392kB) | Preview

Abstract

The Streptococcus pneumoniae capsule is essential for disease pathogenesis, suggesting that even minor genetic changes within the cps locus could potentially have important consequences. Arends et al. have identified 79 different non-synonymous SNPs in the cps locus of 338 19A serotype strains, and shown significant variations between strains in nucleotide sugars content and capsule shedding. Further work is required to characterise whether any of these changes have important functional consequences on capsule/host interactions.

Type: Article
Title: Single-Nucleotide Polymorphisms within the cps Loci: Another Potential Source of Clinically Important Genetic Variation for Streptococcus pneumoniae?
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1128/IAI.00374-21
Publisher version: https://doi.org/10.1128/IAI.00374-21
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10135930
Downloads since deposit
22Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item