Amirthalingam, G; Whitaker, H; Brooks, T; Brown, K; Hoschler, K; Linley, E; Borrow, R; ... Ramsay, ME; + view all Amirthalingam, G; Whitaker, H; Brooks, T; Brown, K; Hoschler, K; Linley, E; Borrow, R; Brown, C; Watkins, N; Roberts, DJ; Solomon, D; Gower, CM; de Waroux, OLP; Andrews, NJ; Ramsay, ME; - view fewer (2021) Seroprevalence of SARS-CoV-2 among Blood Donors and Changes after Introduction of Public Health and Social Measures, London, UK. Emerging Infectious Diseases , 27 (7) pp. 1795-1801. 10.3201/eid2707.203167.

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Abstract

We describe results of testing blood donors in London, UK, for severe acute respiratory disease coronavirus 2 (SARS-CoV-2) IgG before and after lockdown measures. Anonymized samples from donors 17–69 years of age were tested using 3 assays: Euroimmun IgG, Abbott IgG, and an immunoglobulin receptor-binding domain assay developed by Public Health England. Seroprevalence increased from 3.0% prelockdown (week 13, beginning March 23, 2020) to 10.4% during lockdown (weeks 15–16) and 12.3% postlockdown (week 18) by the Abbott assay. Estimates were 2.9% prelockdown, 9.9% during lockdown, and 13.0% postlockdown by the Euroimmun assay and 3.5% prelockdown, 11.8% during lockdown, and 14.1% postlockdown by the receptor-binding domain assay. By early May 2020, nearly 1 in 7 donors had evidence of past SARS-CoV-2 infection. Combining results from the Abbott and Euroimmun assays increased seroprevalence by 1.6%, 2.3%, and 0.6% at the 3 timepoints compared with Euroimmun alone, demonstrating the value of using multiple assays.

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