Van Melkebeke, L;
Korf, H;
Tsochatzis, EA;
van der Merwe, S;
Nevens, F;
Verbeek, J;
(2021)
Treatment of severe alcoholic hepatitis: A systematic review.
Current Opinion in Pharmacology
, 60
pp. 91-101.
10.1016/j.coph.2021.06.011.
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Abstract
Severe alcoholic hepatitis is the most severe form of alcohol-related liver disease. Corticosteroids remain the first choice of treatment. However, they are only effective in a subset of patients and are associated with an increased infection risk. Furthermore, nonresponders to corticosteroids have a poor prognosis with a mortality of 70% over 6 months. As such, there is a high need for a more personalized use of corticosteroids and the development and identification of alternative therapeutic strategies. In this review, we summarize the recent and ongoing randomized controlled trials concerning the treatment of severe alcoholic hepatitis.
| Type: | Article |
|---|---|
| Title: | Treatment of severe alcoholic hepatitis: A systematic review |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.coph.2021.06.011 |
| Publisher version: | http://doi.org/10.1016/j.coph.2021.06.011 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10134643 |
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