UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Application of T cell receptor (TCR) repertoire analysis for the advancement of cancer immunotherapy

Joshi, K; Milighetti, M; Chain, BM; (2022) Application of T cell receptor (TCR) repertoire analysis for the advancement of cancer immunotherapy. Current Opinion in Immunology , 74 pp. 1-8. 10.1016/j.coi.2021.07.006.

[thumbnail of COIMMU-D-21-00070_R1.pdf] Text
COIMMU-D-21-00070_R1.pdf - Accepted version
Access restricted to UCL open access staff until 26 August 2022.

Download (2MB)

Abstract

T cell receptor (TCR) sequencing has emerged as a powerful new technology in analysis of the host–tumour interaction. The advances in NextGen sequencing technologies, coupled with powerful novel bioinformatic tools, allow quantitative and reproducible characterisation of repertoires from tumour and blood samples from an increasing number of patients with a variety of solid cancers. In this review, we consider how global metrics such as T cell clonality and diversity can be extracted from these repertoires and used to give insight into the mechanism of action of immune checkpoint blockade. Furthermore, we explore how the analysis of TCR overlap between repertories can help define spatial and temporal heterogeneity of the anti-tumoural immune response. Finally, we review how analysis of TCR sequence and structure, either of individual TCRs or from sets of related TCRs can be used to annotate the antigenic specificity, with important implications for the development of personalised adoptive cellular immunotherapies.

Type: Article
Title: Application of T cell receptor (TCR) repertoire analysis for the advancement of cancer immunotherapy
DOI: 10.1016/j.coi.2021.07.006
Publisher version: https://doi.org/10.1016/j.coi.2021.07.006
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/10133842
Downloads since deposit
1Download
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item