Chanpong, A;
Cronin, H;
Rampling, D;
Ashworth, M;
Eaton, S;
Rybak, A;
Saliakellis, E;
... Thapar, N; + view all
(2022)
Enhancing the utility of antroduodenal manometry in pediatric intestinal pseudo-obstruction.
Neurogastroenterology and Motility
, 34
(5)
, Article e14259. 10.1111/nmo.14259.
Preview |
Text
Chanpong_et_al_ADM_revised_manuscript_240721_NT_Accepted.pdf - Accepted Version Download (909kB) | Preview |
Abstract
BACKGROUND: Antroduodenal manometry (ADM) and histopathology are currently employed to aid the diagnosis of pediatric intestinal pseudo-obstruction (PIPO). Limited data are available on the reliability of ADM analysis and its correlation with histopathology. We aimed to develop a protocol for enhanced analysis of ADM contractile patterns, including a scoring system, and explore whether this provided better correlation with histopathology. METHODS: Children referred with suspected PIPO between April 2012-December 2019 who underwent both ADM and full-thickness biopsies were included. ADM tracings were analyzed using both standard (conventional ADM) and novel (enhanced ADM) motility parameters. A novel ADM score (GLASS score) was generated based on the enhanced ADM analysis. Conventional and enhanced ADM analyses were then correlated with histopathology. RESULTS: Forty patients were included. Using conventional clinical criteria, 29 of these were diagnosed with PIPO and the other 11 with non-PIPO diagnoses. Twenty-three of the PIPO patients had abnormal histopathology: 6 myopathy, 4 neuropathy, 3 neuro-myopathy, and 10 non-specific changes. No agreement in diagnosis was found between conventional ADM analysis and histopathology (ϰ = 0.068; p = 0.197), whereas the latter significantly correlated with enhanced ADM analysis (ϰ = 0.191; p = 0.003). The enhanced ADM score was significantly higher in PIPO versus non-PIPO (16.0 vs. 8.0; p < 0.001). CONCLUSIONS: As opposed to conventional analysis protocols, the newly developed enhanced ADM analysis and associated score is not only able to discriminate between PIPO and non-PIPO patients, but also between distinct histopathological pathologies. Further studies are required to assess the utility of enhanced ADM analysis in larger populations.
Type: | Article |
---|---|
Title: | Enhancing the utility of antroduodenal manometry in pediatric intestinal pseudo-obstruction |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1111/nmo.14259 |
Publisher version: | https://doi.org/10.1111/nmo.14259 |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
Keywords: | Intestinal pseudo-obstruction; pediatric; antroduodenal manometry; histopathology; small intestine; gastrointestinal motility; scoring system |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
URI: | https://discovery.ucl.ac.uk/id/eprint/10133300 |
Archive Staff Only
![]() |
View Item |