Chen, J;
Chen, X;
Xie, Y;
Sun, Y;
Wang, X;
Hesketh, T;
(2021)
Irritable bowel syndrome and migraine: evidence from Mendelian randomization analysis in the UK Biobank.
Expert Review of Gastroenterology and Hepatology
, 15
(10)
pp. 1233-1239.
10.1080/17474124.2021.1949290.
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Abstract
BACKGROUND: Irritable Bowel Syndrome (IBS) and Migraine are two diseases featuring high prevalence. Previous studies have suggested a relationship between IBS and migraine, although the causal association remains unclear. The authors sought to explore the causal association between IBS and migraine, and to show the importance of migraine prevention in IBS patients. METHODS: This study conducted a Mendelian randomization analysis to explore the association of IBS with migraine. Genetic association with migraine was acquired from the UK Biobank (UKB) genetic databases (cases: 1,072; controls: 360,122). The authors performed estimation using Inverse Variance Weighting (IVW), along with Maximum Likelihood, MR-RAPS, MR-Egger and Weighted Median for sensitivity analysis. Considering possible bias, they also conducted polymorphism, heterogeneity, and directional analysis. RESULTS: The IVW estimation genetically predicted the causal association between IBS and migraine (OR=1.09, 95%CI 1.01 to 1.17, p=0.03). Neither statistical horizontal pleiotropy (MR Egger p=0.42; MR-PRESSO p=0.78) nor possible heterogeneity (IVW Q = 26.15, p=0.80) was found. Reverse causation was also not detected (p steiger<0.01). CONCLUSION: Mendelian randomization analysis supported a potential causal association between IBS and migraine, providing enlightenment for disease prevention and control.
| Type: | Article |
|---|---|
| Title: | Irritable bowel syndrome and migraine: evidence from Mendelian randomization analysis in the UK Biobank |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/17474124.2021.1949290 |
| Publisher version: | https://doi.org/10.1080/17474124.2021.1949290 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Epidemiology, Irritable bowel syndrome, Mendelian randomization, Migraine, UK Biobank |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10130892 |
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