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Methodological review to develop a list of bias items used to assess reviews incorporating network meta-analysis: protocol and rationale

Lunny, C; Tricco, AC; Veroniki, A-A; Dias, S; Hutton, B; Salanti, G; Wright, JM; ... Whiting, P; + view all (2021) Methodological review to develop a list of bias items used to assess reviews incorporating network meta-analysis: protocol and rationale. BMJ Open , 11 (6) , Article e045987. 10.1136/bmjopen-2020-045987. Green open access

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Abstract

INTRODUCTION: Systematic reviews with network meta-analysis (NMA; ie, multiple treatment comparisons, indirect comparisons) have gained popularity and grown in number due to their ability to provide comparative effectiveness of multiple treatments for the same condition. The methodological review aims to develop a list of items relating to biases in reviews with NMA. Such a list will inform a new tool to assess the risk of bias in NMAs, and potentially other reporting or quality checklists for NMAs which are being updated. METHODS AND ANALYSIS: We will include articles that present items related to bias, reporting or methodological quality, articles assessing the methodological quality of reviews with NMA, or papers presenting methods for NMAs. We will search Ovid MEDLINE, the Cochrane library and difficult to locate/unpublished literature. Once all items have been extracted, we will combine conceptually similar items, classifying them as referring to bias or to other aspects of quality (eg, reporting). When relevant, reporting items will be reworded into items related to bias in NMA review conclusions, and then reworded as signalling questions. ETHICS AND DISSEMINATION: No ethics approval was required. We plan to publish the full study open access in a peer-reviewed journal, and disseminate the findings via social media (Twitter, Facebook and author affiliated websites). Patients, healthcare providers and policy-makers need the highest quality evidence to make decisions about which treatments should be used in healthcare practice. Being able to critically appraise the findings of systematic reviews that include NMA is central to informed decision-making in patient care.

Type: Article
Title: Methodological review to develop a list of bias items used to assess reviews incorporating network meta-analysis: protocol and rationale
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/bmjopen-2020-045987
Publisher version: http://dx.doi.org/10.1136/bmjopen-2020-045987
Language: English
Additional information: © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
Keywords: epidemiology, protocols & guidelines, quality in health care, statistics & research methods, Bias, Humans, Meta-Analysis as Topic, Network Meta-Analysis, Publications, Publishing, Systematic Reviews as Topic
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
URI: https://discovery.ucl.ac.uk/id/eprint/10130747
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