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Turnover and activity-dependent transcriptional control of NompC in the Drosophila ear.

Boyd-Gibbins, N; Tardieu, CH; Blunskyte, M; Kirkwood, N; Somers, J; Albert, JT; (2021) Turnover and activity-dependent transcriptional control of NompC in the Drosophila ear. iScience , 24 (5) , Article 102486. 10.1016/j.isci.2021.102486. Green open access

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Abstract

Across their lives, biological sensors maintain near-constant functional outputs despite countless exogenous and endogenous perturbations. This sensory homeostasis is the product of multiple dynamic equilibria, the breakdown of which contributes to age-related decline. The mechanisms of homeostatic maintenance, however, are still poorly understood. The ears of vertebrates and insects are characterized by exquisite sensitivities but also by marked functional vulnerabilities. Being under the permanent load of thermal and acoustic noise, auditory transducer channels exemplify the homeostatic challenge. We show that (1) NompC-dependent mechanotransducers in the ear of the fruit fly Drosophila melanogaster undergo continual replacement with estimated turnover times of 9.1 hr; (2) a de novo synthesis of NompC can restore transducer function in the adult ears of congenitally hearing-impaired flies; (3) key components of the auditory transduction chain, including NompC, are under activity-dependent transcriptional control, likely forming a transducer-operated mechanosensory gain control system that extends beyond hearing organs.

Type: Article
Title: Turnover and activity-dependent transcriptional control of NompC in the Drosophila ear.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.isci.2021.102486
Publisher version: https://doi.org/10.1016/j.isci.2021.102486
Language: English
Additional information: Copyright 2021 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Biological sciences, Molecular biology, Sensory neuroscience
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10128773
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