Treasure, T;
Baum, M;
(2017)
An approach to randomization into surgical clinical trials.
British Journal of Surgery
, 104
(1)
pp. 11-12.
10.1002/bjs.10420.
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Abstract
Recruitment of patients into surgical trials is difficult. One in five surgical RCTs is discontinued early and one in three trials remains unpublished1. This is particularly problematic when a study has a surgical and a non-surgical arm, and in the multimodal treatments that include surgery in many cancer trials. There is a recurring sticking point in randomizing patients because of the inherent difference between a preoperative surgical consultation and counselling patients about randomization. This could be resolved if it is accepted that there is no need for the patient to meet a surgeon until they have been assigned to a study arm involving surgery.
| Type: | Article |
|---|---|
| Title: | An approach to randomization into surgical clinical trials |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/bjs.10420 |
| Publisher version: | https://doi.org/10.1002/bjs.10420 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Surgical procedures, operative |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Mathematics UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Mathematics > Clinical Operational Research Unit |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10127396 |
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