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Short durations of corticosteroids for hospitalised COVID-19 patients are associated with a high readmission rate

Chaudhry, Z; Shawe-Taylor, M; Rampling, T; Cutfield, T; Bidwell, G; Chan, XHS; Last, A; ... Esmail, H; + view all (2021) Short durations of corticosteroids for hospitalised COVID-19 patients are associated with a high readmission rate. Journal of Infection 10.1016/j.jinf.2021.03.002. (In press). Green open access

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Abstract

OBJECTIVE: Our objective was to describe the characteristics of patients admitted, discharged and readmitted, due to COVID-19, to a central London acute-care hospital during the second peak, in particular in relation to corticosteroids use. METHODS: We reviewed patients admitted from the community to University College Hospital (UCH) with COVID-19 as their primary diagnosis between 1st-31st December 2020. Re-attendance and readmission data were collected for patients who re-presented within 10 days following discharge. Data were retrospectively collected. RESULTS: 196 patients were admitted from the community with a diagnosis of COVID-19 and discharged alive in December 2020. Corticosteroids were prescribed in hospital for a median of 5 days (IQR 3-8). 20 patients (10.2%) were readmitted within 10 days. 11/20 received corticosteroids in the first admission of which 10 had received 1-3 days of corticosteroids. Readmission rate in those receiving 1-3 days of corticosteroids was 25%. CONCLUSIONS: Most international guidelines have recommended providing up to 10 days of corticosteroids for severe COVID-19 but stopping on discharge. Our findings show shorter courses of corticosteroids during admission are associated with an increased risk of being readmitted and support continuing the course of corticosteroids after hospital discharge monitored in the virtual ward setting.

Type: Article
Title: Short durations of corticosteroids for hospitalised COVID-19 patients are associated with a high readmission rate
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jinf.2021.03.002
Publisher version: http://dx.doi.org/10.1016/j.jinf.2021.03.002
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: COVID-19, Corticosteroids, Dexamethasone, Hospital, Readmissions
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10126256
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