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Comparison between surface electrodes and ultrasound monitoring to measure TMS evoked muscle contraction

Kaczmarczyk, I; Rawji, V; Rothwell, JC; Hodson-Tole, E; Sharma, N; (2021) Comparison between surface electrodes and ultrasound monitoring to measure TMS evoked muscle contraction. Muscle & Nerve 10.1002/mus.27192. (In press). Green open access

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Abstract

INTRODUCTION: Transcranial magnetic stimulation (TMS) is widely employed to explore cortical physiology in health and disease. Surface electromyography (sEMG) is appropriate for superficial muscles, but cannot be applied easily to less accessible muscles. Muscle ultrasound (mUS) may provide an elegant solution to this problem, but fundamental questions remain. We explore the relationship between TMS evoked muscle potentials and TMS evoked muscle contractions measured with mUS. METHODS: In 10 participants we performed a TMS recruitment curve, simultaneously measuring motor evoked potentials (MEPs) and mUS in biceps (BI), first dorsal interosseous (FDI), tibialis anterior (TA) and the tongue (TO). RESULTS: Resting motor threshold (RMT) measurements and recruitment curves were found to be consistent across sEMG and mUS. DISCUSSION: This work supports the use of TMS-US to study less accessible muscles. The implications are broad but could include the study of a new range of muscles in disorders such as amyotrophic lateral sclerosis.

Type: Article
Title: Comparison between surface electrodes and ultrasound monitoring to measure TMS evoked muscle contraction
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/mus.27192
Publisher version: https://doi.org/10.1002/mus.27192
Language: English
Additional information: Copyright © 2021 The Authors. Muscle & Nerve published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Keywords: amyotrophic lateral sclerosis, electromyography, feature tracking, motor neuron disease, motor evoked potential, muscle ultrasound, transcranial magnetic stimulation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10123301
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