Ramirez, J;
Van Duijvenboden, S;
Tinker, A;
Lambiase, PD;
Munroe, PB;
Orini, M;
(2020)
Sex Differences in the Morphology of RR-Matched T-waves.
In:
Proceedings of 2020 Computing in Cardiology (CinC 2020).
Computing in Cardiology (CinC): Rimini, Italy.
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Abstract
Evidence of sex-related differences in cardiac risk is emerging, but whether these reflect sex-related differences in ventricular electrophysiology remains unclear. Our aim was to quantify T-wave morphological differences between men and women across different leads and RR interval values. We analysed 12-lead ECG recordings from 23,962 participants in the UK Biobank without known cardiovascular disease, and subsequently clustered them into bins of RR interval. In each cluster, we derived a lead and sexspecific mean warped T-wave (MWT). Then, we quantified differences between MWT in men and women in time and amplitude using linear, dw and da, and non-linear markers, d NL w and d NL a . Leads V3 and aVR showed the lowest differences between men and women (median dw, d NL w , da and d NL a of 1.12 ms, 0.69 ms, 3.29 and 1.20, respectively), while V1 showed the largest (5.69 ms, 4.50 ms, 208.94 and 199.45, respectively). Sex-related differences in MWT increased with the RR interval (dw, d NL w , da and d NL a ranging 1.44 - 5.89 ms, 1.23 - 3.97 ms, 8.58 - 28.38 and 1.53 - 4.41, respectively). These values compare to those found for morphological T-wave variations due to large changes in heart rate (5.66 ms, 2.35 ms, 57.61 and 9.51, respectively). These results indicate sex and lead should be considered when using T-wave morphologies for cardiovascular risk prediction.
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