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Sex Differences in the Morphology of RR-Matched T-waves

Ramirez, J; Van Duijvenboden, S; Tinker, A; Lambiase, PD; Munroe, PB; Orini, M; (2020) Sex Differences in the Morphology of RR-Matched T-waves. In: Proceedings of 2020 Computing in Cardiology (CinC 2020). Computing in Cardiology (CinC): Rimini, Italy. Green open access

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Abstract

Evidence of sex-related differences in cardiac risk is emerging, but whether these reflect sex-related differences in ventricular electrophysiology remains unclear. Our aim was to quantify T-wave morphological differences between men and women across different leads and RR interval values. We analysed 12-lead ECG recordings from 23,962 participants in the UK Biobank without known cardiovascular disease, and subsequently clustered them into bins of RR interval. In each cluster, we derived a lead and sexspecific mean warped T-wave (MWT). Then, we quantified differences between MWT in men and women in time and amplitude using linear, dw and da, and non-linear markers, d NL w and d NL a . Leads V3 and aVR showed the lowest differences between men and women (median dw, d NL w , da and d NL a of 1.12 ms, 0.69 ms, 3.29 and 1.20, respectively), while V1 showed the largest (5.69 ms, 4.50 ms, 208.94 and 199.45, respectively). Sex-related differences in MWT increased with the RR interval (dw, d NL w , da and d NL a ranging 1.44 - 5.89 ms, 1.23 - 3.97 ms, 8.58 - 28.38 and 1.53 - 4.41, respectively). These values compare to those found for morphological T-wave variations due to large changes in heart rate (5.66 ms, 2.35 ms, 57.61 and 9.51, respectively). These results indicate sex and lead should be considered when using T-wave morphologies for cardiovascular risk prediction.

Type: Proceedings paper
Title: Sex Differences in the Morphology of RR-Matched T-waves
Event: 2020 Computing in Cardiology (CinC 2020)
Open access status: An open access version is available from UCL Discovery
DOI: 10.22489/CinC.2020.402
Publisher version: https://doi.org/10.22489/CinC.2020.402
Language: English
Additional information: This is an Open Access article published under a Creative Commons Attribution 4.0 International (CC BY 4.0) Licence (https://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine > MRC Unit for Lifelong Hlth and Ageing
URI: https://discovery.ucl.ac.uk/id/eprint/10123268
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