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Semi-solid extrusion 3D printing in drug delivery and biomedicine: Personalised solutions for healthcare challenges

Seoane-Viaño, I; Januskaite, P; Alvarez-Lorenzo, C; Basit, AW; Goyanes, A; (2021) Semi-solid extrusion 3D printing in drug delivery and biomedicine: Personalised solutions for healthcare challenges. Journal of Controlled Release 10.1016/j.jconrel.2021.02.027. (In press).

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Abstract

Three-dimensional (3D) printing is an innovative additive manufacturing technology, capable of fabricating unique objects in a layer-by-layer manner. Semi-solid extrusion (SSE) is a subset of material extrusion 3D printing, based on the sequential deposition of layers of gel or paste to create an object of a desired size and shape. In comparison to other extrusion-based technologies, SSE 3D printing employs low printing temperatures making it suitable for drug delivery and biomedical applications, and the use of disposable syringes provides benefits in meeting critical quality requirements for pharmaceutical use. Besides pharmaceutical manufacture, SSE 3D printing has attracted increasing attention in the field of bioelectronics, particularly in the manufacture of biosensors capable of measuring physiological parameters or as a means to trigger drug release from medical devices. This review begins by highlighting the major printing process parameters and material properties that influence the feasibility of transforming a 3D design into a 3D object, followed by a discussion of the current SSE 3D printing developments and applications in the fields of pharmaceutics, bioprinting and bioelectronics. Finally, the advantages and limitations offered by this technology are explored, focusing on its potential clinical applications and suitability for preparing personalised medicines.

Type: Article
Title: Semi-solid extrusion 3D printing in drug delivery and biomedicine: Personalised solutions for healthcare challenges
Location: Netherlands
DOI: 10.1016/j.jconrel.2021.02.027
Publisher version: https://doi.org/10.1016/j.jconrel.2021.02.027
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: 3D printed drug products, 3D printing, Direct ink writing, Micro-extrusion, Personalised pharmaceuticals and medicines, Rheology and food printing
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/10123254
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