UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Watching synchronous mitochondrial respiration in the retina and its instability in a mouse model of macular degeneration

Kaynezhad, P; Tachtsidis, I; Aboelnour, A; Sivaprasad, S; Jeffery, G; (2021) Watching synchronous mitochondrial respiration in the retina and its instability in a mouse model of macular degeneration. Scientific Reports , 11 (1) , Article 3274. 10.1038/s41598-021-82811-2. Green open access

[thumbnail of s41598-021-82811-2.pdf]
Preview
Text
s41598-021-82811-2.pdf - Published Version

Download (2MB) | Preview

Abstract

MMitochondrial function declines with age and in some diseases, but we have been unable to analyze this in vivo. Here, we optically examine retinal mitochondrial function as well as choroidal oxygenation and hemodynamics in aging C57 and complement factor H (CFH−/−) mice, proposed models of macular degeneration which suffer early retinal mitochondrial decline. In young C57s mitochondrial populations respire in coupled oscillatory behavior in cycles of ~ 8 min, which is phase linked to choroidal oscillatory hemodynamics. In aging C57s, the oscillations are less regular being ~ 14 min and more dissociated from choroidal hemodynamics. The mitochondrial oscillatory cycles are extended in CFH−/− mice being ~ 16 min and are further dissociated from choroidal hemodynamics. Mitochondrial decline occurs before age-related changes to choroidal vasculature, hence, is the likely origin of oscillatory disruption in hemodynamics. This technology offers a non-invasive technique to detect early retinal disease and its relationship to blood oxygenation in vivo and in real time.

Type: Article
Title: Watching synchronous mitochondrial respiration in the retina and its instability in a mouse model of macular degeneration
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41598-021-82811-2
Publisher version: https://doi.org/10.1038/s41598-021-82811-2
Language: English
Additional information: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
Keywords: Biophotonics; Optical spectroscopy
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10123175
Downloads since deposit
29Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item