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Obesity-induced cognitive impairment in older adults: a microvascular perspective

Balasubramanian, P; Kiss, T; Tarantini, S; Nyúl-Tóth, Á; Ahire, C; Yabluchanskiy, A; Csipo, T; ... Ungvari, Z; + view all (2021) Obesity-induced cognitive impairment in older adults: a microvascular perspective. American Journal of Physiology: Heart and Circulatory Physiology , 320 (2) H740-H761. 10.1152/ajpheart.00736.2020.

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Abstract

Over two-thirds of individuals aged 65 and older are obese or overweight in the United States. Epidemiological data show an association between the degree of adiposity and cognitive dysfunction in the elderly. In this review, the pathophysiological roles of microvascular mechanisms, including impaired endothelial function and neurovascular coupling responses, microvascular rarefaction, and blood-brain barrier disruption in the genesis of cognitive impairment in geriatric obesity are considered. The potential contribution of adipose-derived factors and fundamental cellular and molecular mechanisms of senescence to exacerbated obesity-induced cerebromicrovascular impairment and cognitive decline in aging are discussed.

Type: Article
Title: Obesity-induced cognitive impairment in older adults: a microvascular perspective
Location: United States
DOI: 10.1152/ajpheart.00736.2020
Publisher version: https://doi.org/10.1152/ajpheart.00736.2020
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: aging, endothelial dysfunction, metabolic syndrome, neurovascular coupling, senescence
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: https://discovery.ucl.ac.uk/id/eprint/10121529
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