UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Systematic review and meta-analysis of lean mass and mortality: Rationale and study description

Cheung, C-L; Lee, GK-Y; Au, PC-M; Li, GH-Y; Chan, M; Li, H-L; Cheung, BM-Y; ... Wu, C-H; + view all (2021) Systematic review and meta-analysis of lean mass and mortality: Rationale and study description. Osteoporosis and Sarcopenia 10.1016/j.afos.2021.01.001. (In press). Green open access

[img]
Preview
Text
1-s2.0-S2405525521000017-main.pdf - Published version

Download (825kB) | Preview

Abstract

Objectives: Muscle mass is one of the key components in defining sarcopenia and is known to be important for locomotion and body homeostasis. Lean mass is commonly used as a surrogate of muscle mass and has been shown to be associated with increased mortality. However, the relationship of lean mass with mortality may be affected by different clinical conditions, modalities used, cut-off point to define low or normal lean mass, and even types of cancer among cancer patients. Thus, we aim to perform a comprehensive meta-analysis of lean mass with mortality by considering all these factors. / Methods: Systematic search was done in PubMed, Cochrane Library and Embase for articles related to lean mass and mortality. Lean mass measured by dual X-ray absorptiometry, bioelectrical impedance analysis, and computerized tomography were included. / Results: The number of relevant studies has increased continuously since 2002. A total of 188 studies with 98 468 people were included in the meta-analysis. The association of lean mass with mortality was most studied in cancer patients, followed by people with renal diseases, liver diseases, elderly, people with cardiovascular disease, lung diseases, and other diseases. The meta-analysis can be further conducted in subgroups based on measurement modalities, site of measurements, definition of low lean mass adopted, and types of cancer for studies conducted in cancer patients. / Conclusions: This series of meta-analysis provided insight and evidence on the relationship between lean mass and mortality in all directions, which may be useful for further study and guideline development.

Type: Article
Title: Systematic review and meta-analysis of lean mass and mortality: Rationale and study description
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.afos.2021.01.001
Publisher version: https://doi.org/10.1016/j.afos.2021.01.001
Language: English
Additional information: Copyright © 2021 The Korean Society of Osteoporosis. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Lean mass, Sarcopenia, Mortality, Meta-analysis, Systematic review
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy
URI: https://discovery.ucl.ac.uk/id/eprint/10121503
Downloads since deposit
13Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item