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A Common Framework for Integrated and Continuous Biomanufacturing

Coffman, J; Brower, M; Connell-Crowley, L; Deldari, S; Farid, SS; Horowski, B; Patil, U; ... Shultz, J; + view all (2021) A Common Framework for Integrated and Continuous Biomanufacturing. Biotechnology and Bioengineering , 118 (4) pp. 1735-1749. 10.1002/bit.27690. Green open access

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Abstract

There is a growing application of integrated and continuous bioprocessing (ICB) for manufacturing recombinant protein therapeutics produced from mammalian cells. At first glance, the newly evolved ICB has created a vast diversity of platforms. A closer inspection reveals convergent evolution: nearly all of the major ICB methods have a common framework that could allow manufacturing across a global ecosystem of manufacturers using simple, yet effective, equipment designs. The framework is capable of supporting the manufacturing of most major biopharmaceutical ICB and legacy processes without major changes in the regulatory license. This article is protected by copyright. All rights reserved.

Type: Article
Title: A Common Framework for Integrated and Continuous Biomanufacturing
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/bit.27690
Publisher version: https://doi.org/10.1002/bit.27690
Language: English
Additional information: © 2021 AstraZeneca. Biotechnology and Bioengineering published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Keywords: biopharmaceutical, dual-column chromatography, integrated continuous bioprocessing, mammalian cells, perfusion, protein therapeutics
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10120718
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