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Progress towards non-small-cell lung cancer models that represent clinical evolutionary trajectories

Hynds, RE; Frese, KK; Pearce, DR; Grönroos, E; Dive, C; Swanton, C; (2021) Progress towards non-small-cell lung cancer models that represent clinical evolutionary trajectories. Open Biology , 11 (1) , Article 200247. 10.1098/rsob.200247. Green open access

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Abstract

Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide. Although advances are being made towards earlier detection and the development of impactful targeted therapies and immunotherapies, the 5-year survival of patients with advanced disease is still below 20%. Effective cancer research relies on pre-clinical model systems that accurately reflect the evolutionary course of disease progression and mimic patient responses to therapy. Here, we review pre-clinical models, including genetically engineered mouse models and patient-derived materials, such as cell lines, primary cell cultures, explant cultures and xenografts, that are currently being used to interrogate NSCLC evolution from pre-invasive disease through locally invasive cancer to the metastatic colonization of distant organ sites.

Type: Article
Title: Progress towards non-small-cell lung cancer models that represent clinical evolutionary trajectories
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1098/rsob.200247
Publisher version: https://doi.org/10.1098/rsob.200247
Language: English
Additional information: Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
Keywords: cell lines, organoids, patient-derived xenografts, genetically engineered mouse models, cancer evolution, model systems
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10119338
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