Hynds, RE;
Frese, KK;
Pearce, DR;
Grönroos, E;
Dive, C;
Swanton, C;
(2021)
Progress towards non-small-cell lung cancer models that represent clinical evolutionary trajectories.
Open Biology
, 11
(1)
, Article 200247. 10.1098/rsob.200247.
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Abstract
Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide. Although advances are being made towards earlier detection and the development of impactful targeted therapies and immunotherapies, the 5-year survival of patients with advanced disease is still below 20%. Effective cancer research relies on pre-clinical model systems that accurately reflect the evolutionary course of disease progression and mimic patient responses to therapy. Here, we review pre-clinical models, including genetically engineered mouse models and patient-derived materials, such as cell lines, primary cell cultures, explant cultures and xenografts, that are currently being used to interrogate NSCLC evolution from pre-invasive disease through locally invasive cancer to the metastatic colonization of distant organ sites.
| Type: | Article |
|---|---|
| Title: | Progress towards non-small-cell lung cancer models that represent clinical evolutionary trajectories |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1098/rsob.200247 |
| Publisher version: | https://doi.org/10.1098/rsob.200247 |
| Language: | English |
| Additional information: | Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
| Keywords: | cell lines, organoids, patient-derived xenografts, genetically engineered mouse models, cancer evolution, model systems |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10119338 |
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